M.D. Interview Article Published By NAD Research, Inc. Dated July 13, 2023 Titled : “NAD’s Central Role In The Future of Medicine”
NAD Research, Inc. is the only research foundation devoted exclusively to greater scientific understanding of the clinical applications and benefits of NAD—nicotinamide adenine dinucleotide—a foundational molecule found in every cell in the human body.
NAD : A FOUNDATIONAL MOLECULE
NAD is a foundational molecule that plays an essential role in many metabolic and cell regulatory processes—the full implications of which are only now being understood. In addition to its demonstrated benefits for treating addiction, depression, and posttraumatic stress, NAD has been gaining recognition for its role in combating the effects of aging—and for offering powerful possibilities for the treatment of chronic diseases, autoimmune disorders, chronic fatigue, and neurodegenerative diseases like Alzheimer’s and Parkinson’s.
Following Are Selected Verbatim Excerpts From A Recent M.D. Interview Offering Comprehensive Overview of Applications & Efficacies of Medical-grade NAD+
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JULY 13 , 2023 BY NAD RESEARCH , INC.
“NAD’s central role in the future of medicine”
An interview with Dr. Fenton Le Bon, M.D.
M.D.: “Certainly. In the old days, way back when I went to medical school, we believed that NAD simply was the foundational molecule for the production of ATP, which is the basic energy fuel that all cells use. NAD picks up hydrogens from the Krebs cycle and puts them into the electron transport chain in the mitochondria, which produces ATP for energy. Later on we also discovered, through the work of Dr. Ross Grant and others, especially his team in Australia, that NAD is also the foundational molecule for anti-inflammation through the sirtuin system—SIRTS 1 through 6. “
M.D.: “For example, the sirtuin system is intimately involved with the production of superoxide dismutase, which is a primary enzyme associated with reducing reactive oxygen species and free radicals, which are very destructive to cell components and organelles. It turns out that NAD is the primary anti-inflammatory molecule in the sirtuin pathways. NAD is also involved in DNA repair through its involvement with PARP (Poly ADP-ribose polymerase). The main role of PARP is to detect and initiate an immediate cellular response to metabolic, chemical, or radiation-induced DNA damage. NAD is required as the substrate for generating ADP-ribose monomers, which combine to form PARP. DNA repair is the body’s very first step in preventing cancer.”
M.D. “We also know that NAD is essential for eliminating pathogens in the body, through three different receptors on natural killer T cells (CD8, CD38, and CD57). These natural killer cells have to do with the identification of foreign bodies, which would include viruses, bacteria, parasites, cancer cells, and also transplanted tissues (which might possibly be the one contraindication for NAD).”
M.D.: “So NAD is essential for cellular energy production, anti-inflammation, combatting oxidative stress, and disease protection. Focusing just on cancer, we have anecdotal evidence that NAD cream can reduce, if not eliminate, squamous cell carcinomas. Which is not surprising when you think about it, because inflammationtriggered mutations are at the root of many cancers. So there are really three different pathways for NAD to be involved with cancer protection and removal: antiinflammation, DNA repair, and natural killer T cell enhancement.”
M.D.: “All of this is very exciting, and we still are just scratching the surface. Take coronary artery disease, for example, which is the most common cause of death in the United States. Coronary artery disease is caused by cholesterol plus inflammation. It’s not just cholesterol. We all know people with high levels of cholesterol and whistle-clean coronary arteries. We’ve known for many years that coronary artery plaques are created by narrowing in the coronary arteries, and that narrowing is caused by what’s called a foam cell. A foam cell is a macrophage that sort of eats cholesterol, like a PacMan if you will, and dies, and gets incorporated into the cells of the endothelium of the smooth muscle of the coronary arteries, triggering an inflammatory response. So, hyper-inflammation plus cholesterol makes a foam cell, which causes coronary plaques, which causes coronary artery disease, which is the number one killer of people in the United States. This also goes for stroke and vascular disease. However, if you have adequate NAD levels you’ll see a decrease in these inflammatory cycles.”
M.D.: “Inflammation is also the linchpin of cancer, peripheral vascular disease, cerebral vascular disease, and diabetes. Along with coronary artery disease, these are all of our top killers, and NAD is likely to be beneficial in preventing or treating all of them.”
M.D.: “We believe that the future of NAD treatments will be as broad as NAD’s roles are in the body. NAD is the foundational molecule for energy, inflammation and, we believe, cancer protection due to its role in DNA repair. These roles affect every single cell in the body.”
M.D.: “If NAD is the linchpin in every single cell, then it will affect every branch of medicine.”
M.D.: “Now, sometimes people come to me and ask, “How do we know that NAD is such an important molecule? What about all these other molecules that exist in the body and are necessary for health.”
M.D.: “My answer comes down to the principle of energy conservation. A biological system, an organism, is very, very energy efficient. So to appreciate how important a molecule is, you have to ask how much energy the body commits to creating and maintaining this molecule. And you also have to ask, how many different pathways does the body dedicate to producing it?”
M.D.: “It turns out that the body commits significant energy to creating and maintaining NAD levels, through several different mechanisms and pathways—the Preiss-Handler pathway (PHP), generating NAD from nicotinic acid; the de novo synthesis pathway (DNP), generating NAD from tryptophan; and the salvage pathway (SP). The body has also chosen NAD as the single most important molecule to be feeding into ATP, which is the only molecule that all the cells of the body use for energy production. So NAD is very important, and we believe that it will be equally important all across the board of medicine. Cardiologists will use it because cardiac cells depend on it; nephrologists will use it because renal cells depend on it; neurologists will use it because brain cells depend on it; dermatologists will use it because skin cells depend on it; surgeons will use it for post-operative care.”
M.D.: “Surgical use is a special case in itself. We could imagine NAD being used either pre- or post-operatively to inhibit postoperative cognitive decline, which is more prevalent nowadays because the operations are longer and many are taking place in older populations, who are already subject to cognitive decline.”
M.D.: “We can also see NAD used for diabetic wound care and diabetes is rampant, due to our elderly population and to the obesity epidemic. So NAD can play a role in almost any disease system, whether it’s administered intravenously, topically, or sublingually.”
M.D.: “Unfortunately, when we tell people that NAD can be used for all of these various symptoms and diseases, they often become skeptical because we’ve been brainwashed by big pharma to believe that every single symptom and every single disease needs its own separate medication to treat it. But that’s because we’re not used to looking at foundational molecules that already exist in our body. If you look at the mechanisms of a cell and discover a molecule used in all the mechanisms, it’s not surprising that the loss of that molecule will lead to one or many disease states, nor that the replacement or restoration of that molecule will enhance each type of cell’s function and address many diseases.”